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You Asked: What Is Inflammation, And Why Should I Care About It?

From TIME - April 11, 2018

Your body can heal itself, which is pretty miraculous when you sit back and think about it. If you suffer a cut or infectionor if a disease, allergen or virus finds its way into youyour immune system reacts by sending specialized white blood cells to the affected area. These white blood cells can repair damage, stop the spread of infection or illness and in some cases eradicate the intruder. This whole response is called inflammation.

Inflammation is an activation of cells and cell-derived components that have the job of fighting invasions, and in some cases just sponging up or clearing out damaged cells, says Valter Longo, a professor of biological sciences at the University of Southern California and author of The Longevity Diet, a book that partly explores inflammations role in gut diseases.

Your body transports its immune cells primarily through your blood. And as blood rushes to the site of an injury or issue, that accumulated blood can produce heat, swelling and rednessall of which are hallmarks of inflammation, says Dr. Jason Ken Hou, an assistant professor of gastroenterology at Baylor College of Medicine.

Without inflammation, your body would be largely defenseless when faced with injury or illness. But not all inflammation is helpful.

In disease states, the good inflammation becomes chronic, or at least dysfunctional, Longo says. Inflammation either sticks around when it should dissipate, or the immune system directs inflammation at something thats not really a threat.

For example, inflammation can worsen the stiffening of arteries and promote plaque accumulation in some people with high cholesterol, high triglycerides and other risk factors for heart disease. These risk factors can irritate the inner lining of the blood vessels and cause an inflammatory response, says Dr. Michael Miller, a professor of medicine and director of the Center for Preventive Cardiology at the University of Maryland School of Medicine. In some cases, Miller says, inflammation increases the risk for dangerous clots, rather than eradicate the problem.

Many gut disorders are also related to inflammation overload. In Crohns disease and ulcerative colitis, which are inflammatory bowel diseases, the immune system is primed and inflammation is turned on inappropriately, Hou explains. This can damage the lining of the intestine, and that damage can allow gut bacteria to penetrate, which leads to more inflammation, he says.

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